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On the other hand, some studies show that taking a high dosage of vitamin B12, such as 1000 mcg, can be an alternative to vitamin B12 injections for those who are lacking the intrinsic factor protein in their diet, or for those with other conditions that do not allow them to absorb their vitamin B12 intake fully

Another difference is bioavailability

Mater Sci Eng C (2014) 38:2027

Sublingual and nasal B12 sublingual tablets (dissolved under the tongue) and nasal B12 sprays have shown effectiveness for deficiency correction as needle-free alternatives but only when the gut absorption mechanism is intact